Q: How much NMN should I take?
A: Dr David Sinclair has stated he takes 1,000mg per day. The FDA has suggested a minimum of 400mg per day and has estimated that a 68kg person would need around 560mg per day. You may choose to take a quantity within this range to suit your own health objectives.
Q: What Is NMN?
A: Nicotinamide Mononucleotide is an intermediate molecule made in the conversion of both nicotinamide and nicotinamide riboside to NAD. It is a type of molecule called a nucleotide, which is very similar to the building blocks of DNA. NMN is natural compound present in most plants including fruits and vegetables such as broccoli, cabbage, avocado and mushrooms, to name just a few. However you would need to consume many kilograms to attain any useful quantity of NMN this way.
Q: How to take NMN? (Sublingual or Not?)
A: See the following quotes from Dr David Sinclair: Quote “Human clinical trials show that swallowing NAD precursors raises blood NAD levels just fine.” – June 15th 2019 David Sinclair tweet.
Quote “We have previously shown that NMN is absorbed from the gut into blood circulation within 2–3 min and transported into tissues within 10–30 min. NMN is then immediately utilized for NAD+ biosynthesis, significantly increasing NAD+ content in tissues over 60 min.
David Sinclair on his blog: How do I take NMN? Sublingual, nope. No need to read between the lines
You can read in full details here https://lifespanbook.com/sublingual-nope/
NMN is between between 4.0 and 4.5 pH, which is similar to the acidity of tomatoes on the pH scale but less acidic than lemons and oranges.
Prolonged exposure when taken sublingualy could contribute to loss of tooth enamel.
Q: Can I overdose on NMN?
A: Studies using animals, taking 300 mg per kg of body weight (136 mg per pound) and more, daily for 90 days had no harmful effects.
It is also clear that high dose supplementation greatly exceeds the body’s requirement for niacin equivalents, and thus will result in substantial elimination through the urine.
A one year long-term study in 2016 of oral administration of NMN (up to 300 mg/kg) determined it is safe and well-tolerated and does not cause any obvious deleterious or toxic effects in normal wild-type mice (Mills et al., 2016).
From current research there seems no risk in overdosing on NMN.
Q: Is NMN safe?
A: NMN is natural compound present in most plants including fruits and vegetables such as broccoli, cabbage, avocado and mushrooms, to name just a few. However you would need to consume many kilograms to attain any useful quantity of NMN this way. Studies have shown that NMN is Non-toxic.
The first human trials of NMN commenced in Sept 2016 in Japan. Subsequent human studies have been undertaken. Dr David Sinclair completed his phase I study and is now commencing Phase II. If there were safety issue identified in Phase I then Phase II would not go ahead or would be delayed.
Human studies (conducted in Tokyo’s Keio University School of Medicine and the Washington University School of Medicine) are currently in progress (concluding June 1st, 2020) to determine change in insulin sensitivity, and to determine change in beta-cell function over the course of two years with NMN supplementation.
Researchers also expect to gather results on control of blood sugar, dilation of blood vessels, changes in both blood lipid and body fat levels, and changes in the markers for cardiovascular disease.
Q: What is in your NMN capsules?
A: The product complies with WHO, FDA and EU Standards. The only ingredient in Extra LifeSpan NMN Powder is the NMN molecule itself.
Q: NR vs NMN
A: Homeostasis refers to the ability of the body or a cell to seek and maintain a condition of equilibrium or stability within its internal environment when dealing with external changes. A single dose of NR has been shown to increase NAD by up to 270%. However, homeostasis soon kicks in and this declines after a few weeks. It was found that increasing the dosage of NR does not provide any further benefit. Studies have shown NAD+ increases of over 500% measured in the liver (and soleus muscle) after 60 days of supplementation with NMN (Sinclair, 2018).
Studies also show that the huge increase in NAD indicates homeostasis is not limiting the NAD+ increase from NMN supplementation in this study.
Q: Does NMN prevent aging?
A: While science has not yet discovered the key to completely abolish the disease of aging there have been some remarkable leaps forward in this field of study. The most dramatic results have been those showing old mice that look and perform the same as young mice. Below are the three studies that made broke exciting new ground about the potential for reversing aging by restoring NAD+ to youthful levels.
Q: Does NMN need refrigeration?
A: The manufacturer of our NMN capsules recommends that they be stored in a cool, dry place, away from direct sunlight for the best possible shelf life. They advise that Pharmaceutical grade NMN powder used in laboratory trials is usually kept refrigerated and any excess powder is disposed of every few days. These are stringent control measures undertaken for the sake of scientific trials and do not necessarily apply to the everyday usage of NMN capsules. If you do choose to refrigerate your NMN be sure to keep the lid tightly sealed to avoid condensation within the container.
Sinclair 2013 https://www.ncbi.nlm.nih.gov/pubmed/24360282
Mills Long term Study 2016 https://www.ncbi.nlm.nih.gov/pubmed/28068222
Sinclair 2018 https://www.cell.com/cell/pdf/S0092-8674(18)30152-1.pdf
These have ALL been accomplished using NMN.